NDLI: Alterations in Antioxidant Status, Protein Concentration, Acetylcholinesterase, $Na^{+}$, $K^{+}$-ATPase, and $Mg^{2+}$-ATPase Activities in Rat Brain after Forced Swimming

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Alterations in Antioxidant Status, Protein Concentration, Acetylcholinesterase, $Na^{+}$, $K^{+}$-ATPase, and $Mg^{2+}$-ATPase Activities in Rat Brain after Forced Swimming

Content Provider	Scilit
Author	Tsakiris, T. Angelogianni, P. Tesseromatis, C. Tsopanakis, C.
Copyright Year	2005
Description	The aim of this study was to investigate whether exercise stress (short [2 h] or prolonged [5 h] forced swimming in rats) could modulate brain total antioxidant status (TAS), tissue protein concentration, and the activities of acetylcholinesterase (AChE), $Na^{+}$, $K^{+}$-ATPase, and $Mg^{2+}$-ATPase. Protein concentration, TAS and enzyme activities in homogenized rat brain were determined spectrophotometrically. Protein concentration was decreased by 15 % (p < 0.01) and by 30 % (p < 0.001) after 2 h and 5 h of forced swimming, respectively. TAS was decreased by 20 - 25 % after 2 h or 5 h of exercise. AChE was inhibited by 30 % (p < 0.001) and 45 % (p < 0.001) after 2 h and 5 h of forced swimming, respectively. In contrast, $Na^{+}$, $K^{+}$-ATPase and $Mg^{2+}$-ATPase were stimulated by 80 % (p < 0.001) and 40 % (p < 0.001), respectively, after 2 h of swimming and by 100 % (p < 0.001) and 60 % (p < 0.001), respectively, after 5 h of exercise. Control values in nontreated rats were unaltered (p > 0.05). In conclusion, short or prolonged forced swimming induces oxidative stress in rats, probably resulting in a reduction in brain protein concentration and AChE activity. In addition, a $Na^{+}$, $K^{+}$-ATPase and $Mg^{2+}$-ATPase activation was observed under the above mentioned experimental conditions. This stress condition may modulate brain intracellular $Mg^{2+}$ concentration, neural excitability, metabolic energy production, and neurotransmission.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2005-837506.pdf
Ending Page	24
Page Count	6
Starting Page	19
ISSN	01724622
e-ISSN	14393964
DOI	10.1055/s-2005-837506
Journal	International Journal of Sports Medicine
Issue Number	1
Volume Number	27
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2005-05-09
Access Restriction	Open
Subject Keyword	Journal: International Journal of Sports Medicine Brain Oxidative Stress Brain Protein Concentration Acetylcholinesterase
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physical Therapy, Sports Therapy and Rehabilitation Sports Science

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