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Immunomodulatory Activity of Polysaccharide fromAcanthopanax obovatusRoots
| Content Provider | Scilit |
|---|---|
| Author | Ito, H. Shimura, K. |
| Editor | Wang, J. Z. Mao, X. J. |
| Copyright Year | 1991 |
| Description | The effects of the Acanthopanax obovatus polysaccharide (AOPS) as well as its combination with cyclophosphamide (CY) or prednisolone on immune responses were investigated in mice. AOPS (250 mg/kg i.p. × 5) increased the spleen weight and the number of spleen cells, and augmented the phagocytosis of peritoneal macrophages both in normal mice and in immunosuppressed mice. In a haemagglutinin assay AOPS increased the production of specific antibodies and antagonized the suppressive effect of CY. AOPS not only enhanced the degree of in vitro spleen cell-mediated red blood cells (SRBC) hemolysis (quantitative hemolysis of SRBC) but also restored the suppressive effect of CY completely. From these results, AOPS was shown to have an enhancing and a modulating activity on immune responses. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-960111.pdf |
| Ending Page | 336 |
| Page Count | 2 |
| Starting Page | 335 |
| ISSN | 00320943 |
| e-ISSN | 14390221 |
| DOI | 10.1055/s-2006-960111 |
| Journal | Planta Medica |
| Issue Number | 04 |
| Volume Number | 57 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 1991-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Planta Medica Integrative and Complementary Medicine Acanthopanax Obovatus Immunomodulatory Activity Haemagglutinin Titer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Analytical Chemistry Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science |
