l-Proline-Catalysed One-Pot aza-Diels–Alder Reaction in Water: Regioselective Synthesis of Spiro(isoxazolo[5,4-b]pyridine-5,5′-pyrimidine) Derivatives

Content Provider	Scilit
Author	Dommaraju, Yuvaraj Borthakur, Somadrita Prajapati, Dipak
Copyright Year	2018
Description	A simple and efficient l-proline-catalysed synthesis of spiro(isoxazolo[5,4-b]pyridine-5,5′-pyrimidine) derivatives in water has been accomplished through a pseudo five-component one-pot domino aza-Diels–Alder reaction involving 3-amino crotanonitrile, hydroxylamine hydrochloride, aromatic aldehydes and barbituric acids. The main advantages of the present method are mild reaction conditions, modest purification process involving no chromatographic techniques and high yields. The protocol is a good alternative to prepare spiro derivatives with readily available starting materials, which makes the method highly attractive.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0036-1591949.pdf
Ending Page	1198
Page Count	4
Starting Page	1195
ISSN	09365214
e-ISSN	14372096
DOI	10.1055/s-0036-1591949
Journal	Synlett
Issue Number	09
Volume Number	29
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2018-03-20
Access Restriction	Open
Subject Keyword	Organic Chemistry Multicomponent Reaction Aza-diels–alder Reaction
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry