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Tissue-Type Plasminogen Activator (t-PA) and Dilute Blood Clot Lysis Time in Nephrotic Patients
| Content Provider | Scilit |
|---|---|
| Author | Cucuianu, Mircea P. Rus, Horea G. Roman, Stefan Mărcuşu, Codruţa Spînu, Constantin Manasia, Mihai Niculescu, Florin |
| Copyright Year | 1989 |
| Description | When compared to normal weight normolipidemic control subjects, dilute blood clot lysis time was found to be obviously (p <0.001) prolonged in hypertriglyceridemic patients without proteinuria and slightly (p <0.05) accelerated in hyperlipidemic nephrotic patients in spite of their very high levels of plasma fibrinogen. As a result the ratio plasma fibrinogen (mg/dl) per clot lysis time (minutes) was 1.241 ± 0.08 (X ± SEM) in control subjects, 0.574 ± 0.07 in hypertriglyceridemic patients and 2.69 ± 0.172 in nephrotic patients. This finding suggesting that a larger amount of fibrin is rather readily dispersed from dilute blood clots of nephrotic patients was associated with higher levels of plasma t-PA: Ag (9.45 ng/ml ± 1.18 in nephrotic patients versus 5.8 ng/ml ± 1.23 in controls before venous occlusion and respectively 33.1 ng/ml ± 3.83 versus 20.3 ± 3.40 in controls after venous occlusion). Plasminogen activator activity of the euglobulins as assessed by the bovine fibrin-agarose plate was significantly higher in nephrotic patients only after venous occlusion. Plasma samples of nephrotic patients exerted a more potent inhibition of fibrinolysis in a urokinase activated system. This effect was, however, mainly due to the high levels of $α_{2}$ macroglobulin in nephrotic plasma which apparently have little influence on dilute blood clot lysis time. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1646574.pdf |
| Ending Page | 274 |
| Page Count | 5 |
| Starting Page | 270 |
| ISSN | 2567689X |
| DOI | 10.1055/s-0038-1646574 |
| Journal | Thrombosis and Haemostasis |
| Issue Number | 02 |
| Volume Number | 61 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 1989-04-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Thrombosis and Haemostasis Urology and Nephrology Tissue-type Plasminogen Activator Dilute Blood Clot Lysis Time Nephrotic Syndrome |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology |
