Oxymetholone Therapy in Patients with Familial Antithrombin III Deficiency

Content Provider	Scilit
Author	Shibuya, Akira Ninomiya, Haruhiko Nakazawa, Masaki Nagasawa, Toshiro Yoda, Yasuhiro Abe, Tsukasa
Copyright Year	1988
Description	Three patients with familial antithrombin III (ATIII) deficiency, who also have histories of thromboembolism, were treated with oxymetholone in combination with warfarin. Thrombolysis was observed in one patient with acute thrombosis of inferior vena cava during the oxymetholone and warfarin therapy. No further thromboembolic episodes occurred in these patients after initiation of warfarin with or without oxymetholone. The levels of plasma ATIII, $α_{1}$-antitrypsin, plasminogen and Cl-inactivator were significantly increased in all patients after the introduction of oxymetholone therapy. This suggests that oxymetholone augments anticoagulant and fibrinolytic activity. Hence we consider that oxymetholone in combination with warfarin may be possible thrombolytic therapy in patients with familial ATIII deficiency.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1646998.pdf
Ending Page	497
Page Count	3
Starting Page	495
ISSN	2567689X
DOI	10.1055/s-0038-1646998
Journal	Thrombosis and Haemostasis
Issue Number	03
Volume Number	60
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	1988-06-30
Access Restriction	Open
Subject Keyword	Journal: Thrombosis and Haemostasis Familial Antithrombin Iii Deficiency
Content Type	Text
Resource Type	Article
Subject	Hematology