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α-Glucosidase Inhibitory and Anti-Inflammatory Coumestans from the Roots of Dolichos trilobus
| Content Provider | Scilit |
|---|---|
| Author | Jiang, Meng-Yuan Luo, Ming Tian, Kai Li, Yan-Hong Sun, Jing-Xian Lu, Ya Pu, Xiao-Yun Huang, Xiang-Zhong |
| Copyright Year | 2018 |
| Description | Four new coumestans dolichosins A – D (1–4) were isolated from the roots of Dolichos trilobus, together with four known compounds: isosojagol (5), phaseol (6), psoralidin (7), and 4″,5″-dehydroisopsoralidin (8). Their structures were elucidated on the basis of spectroscopic data interpretation, mass spectrometric analyses, and the comparison with literature data of related compounds. The anti-inflammatory activity of these compounds (1–8) was evaluated through the inhibition of nitric oxide production in lipopolysaccharide-activated murine macrophage RAW 264.7 cells, in which compounds 1 and 6 displayed moderate inhibitory activity and no cytotoxic effects. In a α-glucosidase inhibitory assay, compounds 1 and 5–8 exhibited appreciable inhibition on α-glucosidase. Especially compounds 1, 7, and 8 showed $IC_{50}$ values lower than 20.0 µM. |
| Related Links | http://pdfs.semanticscholar.org/7a25/2ad262282c779450c995059bece4c0094dbf.pdf http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-0746-8622.pdf |
| Ending Page | 117 |
| Page Count | 6 |
| Starting Page | 112 |
| ISSN | 00320943 |
| e-ISSN | 14390221 |
| DOI | 10.1055/a-0746-8622 |
| Journal | Planta Medica |
| Issue Number | 02 |
| Volume Number | 85 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2018-10-02 |
| Access Restriction | Open |
| Subject Keyword | Journal: Planta Medica Medicinal Chemistry Dolichos Trilobus Anti-inflammatory Activity Α-glucosidase Inhibitor |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Analytical Chemistry Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science |
