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Mild and Chemoselective Synthesis and Deprotection of Geminal Diacetates Catalyzed by Titanium(IV) Halides
| Content Provider | Scilit |
|---|---|
| Author | MiSuk, Jung Ryu, Jae-Sang Yoon, Jieun Kim, Hak |
| Copyright Year | 2010 |
| Description | A novel, mild, and chemoselective method was developed for the preparation of gem-diacetates from aldehydes and acetic anhydride in the presence of titanium(IV) fluoride (1-5 mol%) under solvent-free conditions at room temperature. The reaction showed a high chemoselectivity toward aldehydes in the presence of ketones. Moreover, titanium(IV) fluoride also catalyzed the deprotection of gem-diacetates to the corresponding aldehydes in water. This efficient and simple method has several benefits, including the use of an inexpensive catalyst, solvent-free conditions, mild reaction temperatures, and high yields, which make it both cost-effective and environmentally friendly. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0029-1218849.pdf |
| Ending Page | 2720 |
| Page Count | 8 |
| Starting Page | 2713 |
| ISSN | 00397881 |
| e-ISSN | 1437210X |
| DOI | 10.1055/s-0029-1218849 |
| Journal | Synthesis |
| Issue Number | 16 |
| Volume Number | 2010 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2010-06-25 |
| Access Restriction | Open |
| Subject Keyword | Journal: Synthesis Organic Chemistry Protecting Groups |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Catalysis |
