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Can Endocan Predict Late-Onset Neonatal Sepsis?
| Content Provider | Scilit |
|---|---|
| Author | Tayman, Cuneyt Okur, Nilufer Serkant, Utku Cakir, Ufuk Halil, Halit Oncel, Mehmet Yekta Oguz, Serife Suna Buyuktiryaki, Mehmet |
| Copyright Year | 2018 |
| Description | Objective Endocan, a proteoglycan secreted by endothelial cells, plays a role in the pathogenesis of sepsis. Endocan is an effective diagnostic and prognostic biomarker of sepsis in adult patients. We evaluate the utility of endocan as a new biomarker in the recognition of late-onset neonatal sepsis (LOS) in preterm infants. Methods This study included preterm infants at gestational age ≤ 32 weeks diagnosed with LOS. Sepsis was diagnosed in the presence of three or more clinical findings plus significant elevation of C-reactive protein (CRP) or interleukin 6 (IL-6) levels. Blood samples were obtained to determine leukocyte count, CRP, IL-6, and endocan levels immediately after the sepsis diagnosis and on the 3rd and 7th day after diagnosis. Results A total of 102 preterm infants, 52 with LOS (21 proven, 31 suspected sepsis) and 50 controls, were included in the study. Mean leukocyte count, serum CRP, IL-6, and endocan levels were significantly higher in the LOS group compared with healthy controls (p < 0.001) at enrolment. Serial measurements showed no significant difference in CRP and IL-6 levels between the proven and suspected sepsis groups, while endocan levels were significantly higher at enrolment and on day 7 in the proven sepsis group (p = 0.003 and p = 0.01, respectively). The endocan levels of preterm infants who died were significantly higher at all time points (p < 0.001, p = 0.001, and p = 0.004, respectively). Conclusion Endocan is an effective, reliable, and promising new biomarker for detecting LOS in preterm infants. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1675239.pdf |
| Ending Page | 102 |
| Page Count | 7 |
| Starting Page | 096 |
| ISSN | 13057707 |
| DOI | 10.1055/s-0038-1675239 |
| Journal | Journal of Pediatric Infectious Diseases |
| Issue Number | 03 |
| Volume Number | 14 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2018-10-24 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Pediatric Infectious Diseases Infectious Diseases Late-onset Neonatal Sepsis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Pediatrics, Perinatology and Child Health |
