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A Concise Formal Synthesis of Unnatural (+)-Aphanorphine from (2S,4R)-4-Hydroxyproline
| Content Provider | Scilit |
|---|---|
| Author | Zhai, Hong Bin Ma, Zhiqiang |
| Copyright Year | 2006 |
| Description | (-)-Aphanorphine methyl ether was synthesized in ten steps from commercially available (2S,4R)-4-hydroxyproline, featuring the C-2 configuration inversion of an intermediate amide and intramolecular Friedel-Crafts reaction. The present work constitutes a formal synthesis of unnatural (+)-aphanorphine. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-956499.pdf |
| Ending Page | 0163 |
| Page Count | 3 |
| Starting Page | 0161 |
| ISSN | 09365214 |
| e-ISSN | 14372096 |
| DOI | 10.1055/s-2006-956499 |
| Journal | Synlett |
| Issue Number | 1 |
| Volume Number | 2007 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2006-12-20 |
| Access Restriction | Open |
| Subject Keyword | Organic Chemistry Configuration Inversion Intramolecular Friedel-crafts |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry |