NDLI: Synthesis and Biological Evaluation of Carbocyclic Nucleosides with 2′,3′-Dihomo-xylo-carbocyclic or Carbocyclic Fused to a Tetrahydrofuran Ring

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Synthesis and Biological Evaluation of Carbocyclic Nucleosides with 2′,3′-Dihomo-xylo-carbocyclic or Carbocyclic Fused to a Tetrahydrofuran Ring

Content Provider	Scilit
Author	Fernández, Franco Figueira, María Caamaño, Olga Rodríguez-Borges, J. Balzarini, Jan Clercq, Erik De
Copyright Year	2004
Description	New purinyl 2′,3′-dihomo-xylo-carbocyclic pentafuranosides and carbocyclic nucleosides fused with tetrahydrofuran ring were synthesized from (±)-c-4-amino-r-1,c-2,t-3-cyclopentanetrimethanol (8). The strongly acid medium in which the purine system was completed on pyrimidine derivative 9 caused condensation of the cis-hydroxymethyl groups, giving rise to a 3-oxabicyclo[3.3.0]octane structure. None of the new compounds exhibited more than very modest antiviral or antitumor activity.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2004-829141.pdf
Ending Page	1995
Page Count	5
Starting Page	1991
ISSN	00397881
e-ISSN	1437210X
DOI	10.1055/s-2004-829141
Journal	Synthesis
Issue Number	12
Volume Number	2004
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2004-07-13
Access Restriction	Open
Subject Keyword	Journal: Synthesis Organic Chemistry Xylo-carbocyclic Nucleosides Tetrahydrofuran Derivatives Antitumoral Activity
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

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