NDLI: Efficient Access to Isoquinolines via Rhodium-Catalyzed Oxidative Annulation of Pyridyl C–H Bonds Directed by Carbonyl with Internal Alkynes

Content Provider	Scilit
Author	Li ∗, Fuwei Shi, Lijun Wen, Mingshan
Copyright Year	2020
Description	An efficient synthesis of amino-substituted isoquinolines via Rh(III)-catalyzed oxidative [2+2+2] annulation of pyridines with alkynes has been developed, which is cooperatively enabled by a directing carbonyl and steric hindrance adjacent to the amino group of the pyridine, via a six-membered rhodacyclic intermediate without coordination with the pyridinic nitrogen. The establishment of this C–H activation strategy also paves the way for other oxidative transformations of heterocyclic C–H bonds.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1707387.pdf
Ending Page	546
Page Count	9
Starting Page	538
ISSN	00397881
e-ISSN	1437210X
DOI	10.1055/s-0040-1707387
Journal	Synthesis
Issue Number	03
Volume Number	53
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2020-09-15
Access Restriction	Open
Subject Keyword	Journal: Synthesis Organic Chemistry Oxidative [2+2+2] Annulation Cooperative Catalysis
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

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