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Immune and Inflammatory Response in Atopic Elite Endurance Athletes
| Content Provider | Scilit |
|---|---|
| Author | Teixeira, Renata Nakata Leite, Gerson Dos Santos Gorjao, Renata Palmeira, Patricia Santos, Cesar Miguel Momesso Zambonatto, Raquel de Oliveira, Heloisa Helena Levada, Adriana Cristina Fiks, Iara Nely Carvalho, Celso Ricardo Fernandes |
| Copyright Year | 2018 |
| Description | The present study aimed to compare the immune and inflammatory responses between atopic (n=20) and non-atopic (n=39) elite endurance athletes. Fifty-nine elite runners and triathletes were assessed for the following measurements: $Th_{1}$, $Th_{2}$ and lymphocyte phenotyping and plasma levels of cortisol, chemokines, inflammatory cytokines and specific immunoglobulin E (IgE). Levels of salivary IgA, allergic symptoms and training data were also evaluated. No difference was observed in baseline lymphocyte levels. However, the $Th_{1}$ lymphocytes of atopic athletes presented a lower response after activation. In contrast to this result, levels of salivary IgA and CXCL9 chemokine were higher in the atopic athletes. It was observed that the volume of training per week was linearly associated with $Th_{1}$ levels, allergic symptoms and IgE levels. In addition, linear multiple regression analysis demonstrated that the volume of training was the only factor associated with allergic symptoms in atopic athletes (r=0.53; p=0.04). These results suggest that compared to non-atopic athletes, atopic athletes present a reduced $Th_{1}$ response and higher levels of salivary IgA. Training volume is associated with the immune response and allergic symptoms, which suggests that they may play a role in the atopy in elite endurance athletes. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-0633-9001.pdf |
| Ending Page | 725 |
| Page Count | 6 |
| Starting Page | 720 |
| ISSN | 01724622 |
| e-ISSN | 14393964 |
| DOI | 10.1055/a-0633-9001 |
| Journal | International Journal of Sports Medicine |
| Issue Number | 09 |
| Volume Number | 39 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2018-06-25 |
| Access Restriction | Open |
| Subject Keyword | Journal: International Journal of Sports Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Physical Therapy, Sports Therapy and Rehabilitation Sports Science |
