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Analgesic, Antipyretic and Anti-Inflammatory Properties ofEuphorbia hirta
| Content Provider | Scilit |
|---|---|
| Author | Lanhers, Marie-Claire Fleurentin, Jacques Dorfman, Pierre Mortier, François Pelt, Jean-Marie |
| Copyright Year | 1991 |
| Description | Lyophilised aqueous extract of Euphorbia hirta L. (Euphorbiaceae) has been evaluated for analgesic, antipyretic and anti-inflammatory properties in mice and rats, in order to complete its activity profile, after the confirmation of the existence of a central depressant activity particularly expressed by a strong sedative effect, associated with anxiolytic effects. This study leads us to the conclusion that this plant extract exerts central analgesic properties. Such a dose-dependent action was obtained against chemical (writhing test) and thermic (hot plate test) stimuli, respectively, from the doses of 20 and 25 mg/kg and it was inhibited by a naloxone pretreatment, a specific morphinic antagonist compound. An antipyretic activity was obtained at the sedative doses of 100 and 400 mg/kg, on the yeast-induced hyperthermia. Finally, significant and dose-dependent anti-inflammatory effects were observed on an acute inflammatory process (carrageenan-induced edema test in rats) from the dose of 100 mg/kg. On the other hand, plant extract remained inactive on chronic processes such as Freund's adjuvant-induced rheumatoid arthritis, after a chronic treatment during fourteen days at the daily dose of 200 or 400 mg/kg; however, if inefficacy was observed on rat backpaws edema and on loss of weight, the aqueous extract reduced the inflammatory hyperalgia. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-960079.pdf |
| Ending Page | 231 |
| Page Count | 7 |
| Starting Page | 225 |
| ISSN | 00320943 |
| e-ISSN | 14390221 |
| DOI | 10.1055/s-2006-960079 |
| Journal | Planta Medica |
| Issue Number | 03 |
| Volume Number | 57 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 1991-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Planta Medica Integrative and Complementary Medicine Central Analgesics Anti-inflammatory Compounds |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Analytical Chemistry Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science |
