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Growth Hormone Binding to Cultured Preadipocytes from Obese fa/fa Rats Increases during Cell Differentiation
| Content Provider | Scilit |
|---|---|
| Author | Landron, D. Dugail, I. Ardouin, B. Quignard-Boulangé, A. |
| Editor | Postel-Vinay, M. C. |
| Copyright Year | 1987 |
| Description | Preadipocytes from 7 day-old obese Zucker rats and from their lean littermates were grown in primary culture. Specific binding of human growth hormone (hGH) to the cells is demonstrated. There is no change in hGH binding to Preadipocytes from lean animals before (day 5 of the culture) and after adipose conversion (day 12). Moreover, addition of insulin to the culture medium does not affect the specific binding of$ ^{125}$I-hGH to the cells. On the contrary, when 1 nM insulin is added to the culture medium of preadipocytes from obese rats, the specific binding of$ ^{125}$I-hGH is enhanced during the cell differentiation, with a 3-fold increase in the number of binding sites. The functional significance of these additional GH sites in differentiated preadipocytes from obese rats has to be examined. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1011837.pdf |
| Ending Page | 406 |
| Page Count | 4 |
| Starting Page | 403 |
| ISSN | 00185043 |
| e-ISSN | 14394286 |
| DOI | 10.1055/s-2007-1011837 |
| Journal | Hormone and Metabolic Research |
| Issue Number | 09 |
| Volume Number | 19 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 1987-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Hormone and Metabolic Research Endocrinology and Metabolism Key-words Growth Hormone Binding Sites Preadipocytes in Primary Culture Cell Differentiation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Endocrinology, Diabetes and Metabolism Biochemistry Clinical Biochemistry Endocrinology |
