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Gluconeogenesis from Acetone in Diabetic Rats
| Content Provider | Scilit |
|---|---|
| Author | Hetenyi, Geza Byers, Mary Ferrarotto, Catherine |
| Copyright Year | 1987 |
| Description | Previous investigations have demonstrated that acetone is a true, if minor precursor of glucose in vivo. In diabetic rats 1.30 % of the carbon atoms of circulating glucose arises from acetone, whereas 0.67 % does in normal 3-day fasted animals. Calculated from these fractions and the turnover rate of glucose, 48 μg/kg. min aceton-carbon is converted to glucose-carbon in diabetic and 16 μg/kg. min in normal rats. In both groups of rats the labelling of plasma lactate was stronger than that of glucose. In view of these results we conclude that: (1) the transfer of C-atoms from acetone to glucose increases in diabetes; (2) acetone remains a minor source of glucose even in ketonemic diabetic rats. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1011763.pdf |
| Ending Page | 145 |
| Page Count | 3 |
| Starting Page | 143 |
| ISSN | 00185043 |
| e-ISSN | 14394286 |
| DOI | 10.1055/s-2007-1011763 |
| Journal | Hormone and Metabolic Research |
| Issue Number | 04 |
| Volume Number | 19 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 1987-04-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Hormone and Metabolic Research Key-words Diabetes |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Endocrinology, Diabetes and Metabolism Biochemistry Clinical Biochemistry Endocrinology |
