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An Expedient Synthesis of 5-Substituted Imidazo[1,2-c]quinazolines
| Content Provider | Scilit |
|---|---|
| Author | Korshin, Edward E. Sabirova, Leila A. Levin, Yakov A. |
| Copyright Year | 2012 |
| Description | An efficient three-step synthesis of 5-substituted 2,3-dihydroimidazo[1,2-c]quinazolines and imidazo[1,2-c]quinazolines was elaborated. 2-(2-Aminophenyl)-4,5-dihydro-1H-imidazole, prepared by phosphorus pentasulfide catalyzed condensation of 2-aminobenzonitrile with ethylenediamine, smoothly reacted with aldehydes to give the corresponding 2,3,5,6-tetrahydroimidazo[1,2-c]quinazolines. The CH–NH fragments of the latter were subjected to selective oxidative dehydrogenation with one equivalent of potassium permanganate on silica gel to give 2,3-dihydroimidazo[1,2-c]quinazolines. With two equivalents of potassium permanganate on silica gel, a one-pot exhaustive dehydrogenation to imidazo[1,2-c]quinazolines was accomplished. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0032-1316802.pdf |
| Ending Page | 3522 |
| Page Count | 11 |
| Starting Page | 3512 |
| ISSN | 00397881 |
| e-ISSN | 1437210X |
| DOI | 10.1055/s-0032-1316802 |
| Journal | Synthesis |
| Issue Number | 22 |
| Volume Number | 44 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2012-10-17 |
| Access Restriction | Open |
| Subject Keyword | Journal: Synthesis Organic Chemistry Nitrogen Heterocycles Heterogeneous Catalysis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Catalysis |
