Loading...
Please wait, while we are loading the content...
Similar Documents
Serum Fetuin-A and Insulin Levels in Classic Congenital Adrenal Hyperplasia
| Content Provider | Scilit |
|---|---|
| Author | Kurnaz, Erdal Çetinkaya, Semra Özalkak, Şervan Bayramoğlu, Elvan Demirci, Gülşah Öztürk, Hasan Serdar Erdeve, Şenay Savaş Aycan, Zehra |
| Copyright Year | 2020 |
| Description | Androgens play a pivotal role in non-reproductive organs such as the kidney, heart, liver, and pancreas. As androgen receptors are expressed in pancreatic and liver cells, excess testosterone can result in hypersecretion of insulin and fetuin-A, a protein produced in the liver. The expression of fetuin-A, a natural inhibitor of tyrosine kinase activity in muscle and liver, leads to insulin resistance. In addition, insulin and fetuin-A levels are thought to be affected by drugs such as glucocorticoids (GCs) and fludrocortisone. However, whether fetuin-A and insulin levels are affected by androgens and GCs in patients with classic congenital adrenal hyperplasia (CAH) is unknown. This cross-sectional study included 56 CAH patients and 70 controls. Analyses were stratified by sex and prepubertal/pubertal status to control for potential changes in serum metabolic/inflammatory markers associated with the production of sex steroids. Fasting blood glucose, insulin, triglyceride, total cholesterol, high density lipoprotein-cholesterol, aspartate aminotransferase, alanine aminotransferase, fetuin-A, and high-sensitivity C-reactive protein (hs-CRP) levels were measured in blood samples. In addition, 17α-hydroxyprogesterone, androstenedione, total testosterone, free testosterone, and dehydroepiandrosterone sulfate levels were measured before medication was administered. Insulin and fetuin-A levels were significantly higher in CAH patients than in controls. The unfavourably high levels of these substances exhibited a positive correlation with total and free testosterone. Regression analysis revealed that fetuin-A and free testosterone were the only independent predictors of the insulin level, while insulin and free testosterone levels significantly predicted the fetuin-A level $(R^{2=}$42.7% and 59.8%). Differences were also observed in triglyceride and hs-CRP levels between the pubertal and prepubertal groups. We conclude that serum fetuin-A and insulin levels may be associated with androgens in CAH patients. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1116-2173.pdf |
| Ending Page | 659 |
| Page Count | 6 |
| Starting Page | 654 |
| ISSN | 00185043 |
| e-ISSN | 14394286 |
| DOI | 10.1055/a-1116-2173 |
| Journal | Hormone and Metabolic Research |
| Issue Number | 09 |
| Volume Number | 52 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2020-02-27 |
| Access Restriction | Open |
| Subject Keyword | Journal: Hormone and Metabolic Research Endocrinology and Metabolism Congenital Adrenal Hyperplasia Alpha-2-hs-glycoprotein Insulin Resistance |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Endocrinology, Diabetes and Metabolism Biochemistry Clinical Biochemistry Endocrinology |
