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Versatile Selective α-Carboxylic Acid Esterification of N-Protected Amino Acids and Peptides by Alcalase
| Content Provider | Scilit |
|---|---|
| Author | Quaedflieg, Peter Nuijens, Timo Cusan, Claudia Kruijtzer, John Rijkers, Dirk Liskamp, Rob |
| Copyright Year | 2009 |
| Description | Under continuous removal of water, the industrial protease Alcalase allows selective synthesis of α-carboxylic acid methyl, ethyl, benzyl, allyl, 2-(trimethylsilyl)ethyl, and tert-butyl esters of amino acids and peptides under mild conditions in very high yields. The purified yields range from 72% to 92%. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0028-1083362.pdf |
| Ending Page | 814 |
| Page Count | 6 |
| Starting Page | 809 |
| ISSN | 00397881 |
| e-ISSN | 1437210X |
| DOI | 10.1055/s-0028-1083362 |
| Journal | Synthesis |
| Issue Number | 05 |
| Volume Number | 2009 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2009-02-11 |
| Access Restriction | Open |
| Subject Keyword | Journal: Synthesis Organic Chemistry Protecting Groups |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Catalysis |