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Enantioselective Organocatalytic Michael Additions of Aldehydes to Enones
| Content Provider | Scilit |
|---|---|
| Copyright Year | 2005 |
| Description | The authors report that the addition of an appropriate achiral cocatalyst is important for the regioselectivity (Michael versus aldol additions) in the described reaction. Various cocatalysts with hydrogen bond donors were tested and those with adjacent hydrogen bond donors (i.e. catechol derivatives) provided the best results. NMR experiments showed that the imidazolidinone catalyst likely produced an enamine with E configuration, which was preformed and a competent nucleophile in the Michael addition. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2005-916112.pdf |
| Ending Page | 0258 |
| Page Count | 1 |
| Starting Page | 0258 |
| ISSN | 18611958 |
| e-ISSN | 1861194X |
| DOI | 10.1055/s-2005-916112 |
| Journal | Synfacts |
| Issue Number | 02 |
| Volume Number | 2005 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2005-10-21 |
| Access Restriction | Open |
| Subject Keyword | Journal: Synfacts Organic Chemistry |
| Content Type | Text |
| Resource Type | Article |