NDLI: Nucleotides XXIX.1Solution Synthesis of Protected Di-2′-deoxynucleoside Phosphotriesters and Thiophosphotriesters via the Phosphoramidite Approach

Content Provider	Scilit
Author	Pfleiderer, W.
Editor	Beiter, A. H.
Copyright Year	1989
Description	The synthesis of the fully protected 16 possible natural di-2′-deoxynucleoside phosphotriesters 6aa-dd and 16 thiophosphotriesters 7aa-dd was achieved by the phosphoramidite approach in solution in preparative scale. The 5′-O-dimethoxytrityl-2′-deoxyribonucleoside 3′-[2-(p-nitrophenyl)ethyl] phosphoromorpholidites 3a-d and the 3′-O-benzyl-2′-deoxyribonucleosides 4a-d were used as starting materials.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-1989-27299.pdf
Ending Page	500
Page Count	4
Starting Page	497
ISSN	00397881
e-ISSN	1437210X
DOI	10.1055/s-1989-27299
Journal	Synthesis
Issue Number	07
Volume Number	1989
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	1989-01-01
Access Restriction	Open
Subject Keyword	Journal: Synthesis Organic Chemistry Deoxynucleoside Phosphotriesters Thiophosphotriesters Phosphoromorpholidites
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

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Nucleotides XXIX.1Solution Synthesis of Protected Di-2′-deoxynucleoside Phosphotriesters and Thiophosphotriesters via the Phosphoramidite Approach