NDLI: Synthesis and Activity of Phenyl Derivatives Containing 5,6-Dimethylthieno[2,3-d]pyrimidin-4(1H)-one or 4H-Pyrimido [5,4-b] indol-4-one Heterocyclic System as Potential Non-steroidal Anti-inflammatory Drugs

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Synthesis and Activity of Phenyl Derivatives Containing 5,6-Dimethylthieno[2,3-d]pyrimidin-4(1H)-one or 4H-Pyrimido [5,4-b] indol-4-one Heterocyclic System as Potential Non-steroidal Anti-inflammatory Drugs

Content Provider	Scilit
Author	Santagati, Andrea Granata, Giuseppe Santagati, Maria Cutuli, Vincenza Mangano, Nunzio Guido Caruso, Antonina
Copyright Year	2002
Description	The synthesis, the analgesic and anti-inflammatory activities of two series of phenyl derivatives containing 5,6-dimethylthieno[2,3-d]pyrimidin-4(1H)-one and 4H-pyrimido[5,4-b]indol-4-one system, respectively, are reported. Two of these derivatives, 6A and 9B, showed interesting activities. The results of the pharmacological assays are discussed. Synthese und Aktivitäten von Phenyl-Derivaten mit heterozyklischen 5,6-Dimethyl-thieno[2,3-d]pyrimidin-4(1H)-on-oder 4H-Pyrimido[5,4-b]indol-4-on-Systemen als wirksame nicht-steroidale entzündungshemmende Wirkstoffe Die Synthese sowie die analgetischen und entzündungshemmenden Aktivitäten von zwei Serien von Phenyl-Derivaten, die 5,6-Dimethylthieno[2,3-d]pyrimidin-4(1H)-on-beziehungsweise 4H-Pyrimido [5,4-b] indol-4-on-Systeme enthalten, wurden untersucht. Zwei dieser Derivate (6A und 9B) zeigten interessante Wirkungen. Die Ergebnisse der pharmakologischen Untersuchungen werden diskutiert.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0031-1299913.pdf
Ending Page	454
Page Count	7
Starting Page	448
ISSN	00044172
e-ISSN	16167066
DOI	10.1055/s-0031-1299913
Journal	Arzneimittelforschung
Issue Number	06
Volume Number	52
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2002-06-01
Access Restriction	Open
Subject Keyword	Journal: Arzneimittelforschung Medicinal Chemistry Anti-inflammatories 6-dimethyl-thieno[2 3-d]pyrimidin-4(1h)-one Phenyl Derivatives 4-b]indol-4-one Phenyl Derivatives
Content Type	Text
Resource Type	Article
Subject	Drug Discovery

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