NDLI: Synthesis of β-Lactams via Ring Opening of a Serine Derived Aziridine

Content Provider	Scilit
Author	Turner, John J. Sikkema, Friso D. Filippov, Dmitri V. van der Marel, Gijs A. van Boom, Jacques H.
Copyright Year	2001
Description	Serine derived aziridine 15 was successfully ring-opened with amino acid esters to give diaminopropionic acid derivatives in excellent yield and regioselectivity. These compounds were cyclised to form the corresponding β-lactams in good overall yield. One example was fully deprotected to give target compound 1 (n = 1, R = Me) in excellent yield.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2001-18090.pdf
Ending Page	1730
Page Count	4
Starting Page	1727
ISSN	09365214
e-ISSN	14372096
DOI	10.1055/s-2001-18090
Journal	Synlett
Issue Number	11
Volume Number	2001
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2001-10-29
Access Restriction	Open
Subject Keyword	Organic Chemistry Freidinger Lactams Mitsunobu Reaction Nitrobenzenesulfonamides Stereoselective Synthesis
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry

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