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In Vivo and In Vitro Effects of Cholecystokinin Octapeptide on the Release of Growth Hormone in Rats
| Content Provider | Scilit |
|---|---|
| Author | Matsumura, M. Yamanoi, A. Yamamoto, S. Mori, H. Saito, S. |
| Copyright Year | 1984 |
| Description | The effect of Cholecystokinin Octapeptide (CCK-8) on the release of growth hormone (GH) in rats was studied in vivo and in vitro. Intravenous injection of 5 μg/100 g BW of CCK-8 resulted in significant increase in the plasma GH level after 10 and 20 min. CCK-8 at concentrations of $10^{-11}$M to $10^{-7}$M also caused dose-dependent stimulation of GH release from dispersed cells of rat anterior pituitary. On the other hand, somatostatin (SRIF) inhibited GH release from dispersed cells of rat anterior pituitary in a dose-related manner at concentrations of $10^{-7}$M to $10^{-9}$M. Release of GH from the cells was increased by addition of $K^{+}$ at high concentration (50 mM) in a $Ca^{++}$-dependent manner. Addition of $10^{-3}$M verapamil to the incubation medium inhibited CCK-8-induced GH release from the cells. Addition of SRIF $(10^{-7}$M) to the incubation medium inhibited GH release from the cells induced by CCK-8 or high $K^{+}$ (50 mM). These results indicate that CCK-8 acts directly on the anterior pituitary cells to stimulate GH release and that calcium ion is involved in the mechanism of this effect. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1014869.pdf |
| Ending Page | 630 |
| Page Count | 5 |
| Starting Page | 626 |
| ISSN | 00185043 |
| e-ISSN | 14394286 |
| DOI | 10.1055/s-2007-1014869 |
| Journal | Hormone and Metabolic Research |
| Issue Number | 12 |
| Volume Number | 16 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 1984-12-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Hormone and Metabolic Research Endocrinology and Metabolism Key-words: Cholecystokinin Octapeptide |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Endocrinology, Diabetes and Metabolism Biochemistry Clinical Biochemistry Endocrinology |
