NDLI: Synthesis, Antimicrobial Evaluation of Substituted Indole and Nitrobenzenamine based Cr(III), Mn(III) and Fe(III) Metal Complexes

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Synthesis, Antimicrobial Evaluation of Substituted Indole and Nitrobenzenamine based Cr(III), Mn(III) and Fe(III) Metal Complexes

Content Provider	Scilit
Author	Sharma, Preeti Singh, Varun Kumar Kumar, Gajendra
Copyright Year	2021
Description	Schiff base ligand (E)-5-methyl-3-(1-(4-nitrophenylimino)ethyl)-1H-indol-2-amine was synthesized by the condensation of 1-(2-amino-5-methyl-1H-indol-3-yl)ethanone and 4-nitrobenzenamine in methanol at 70$ ^{o}$C. The prepared Schiff base ligand doped with Cr(III), Mn(III) and Fe(III) ion, respectively and it is denoted as $[M(C_{34}H_{32}N_{8}O_{4})X]X_{2}$. The complexes have been characterized with the help of elemental analysis, conductance measurements, magnetic measurements and their structural configuration have been determined by various spectroscopic (electronic, IR,$ ^{1}$H NMR,$ ^{13}$C NMR, GCMS) techniques. Electronic and magnetic moments of the complexes indicate that the geometry of the metal center was five coordinate square pyramidal. These metal complexes were also tested for their antimicrobial activities to assess their inhibiting potential against Staphylococcus aureus, Bacillus subtilis (positive bacteria) and Pseudomonas aeruginosa, Escherichia coli, Salmonella typhi (negative bacteria) and fungi Rizoctonia sp., Aspergillus sp., Penicillium sp. $[Cr(C_{34}H_{32}N_{8}O_{4})OAc](OAc)_{2}$ shows best antimicrobial activity against all the pathogens. Received: 27 March 2021 Accepted: 08 June 2021 Publication Date: 22 July 2021 (online) © 2021. Thieme. All rights reserved. Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1527-1307.pdf
Ending Page	461
Page Count	7
Starting Page	455
ISSN	21949379
e-ISSN	21949387
DOI	10.1055/a-1527-1307
Journal	Drug Research
Issue Number	08
Volume Number	71
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2021-07-22
Access Restriction	Open
Subject Keyword	Journal: Drug Research Inorganic Chemistry Schiff Base Metal Complexes Antimicrobial Activity Spectroscopic Study
Content Type	Text
Resource Type	Article
Subject	Medicine Drug Discovery

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