NDLI: Preparation of 2-Fluoro-3-aminophenylboronates via Directed ortho-Metalation

Please wait, while we are loading the content...

Preparation of 2-Fluoro-3-aminophenylboronates via Directed ortho-Metalation

Content Provider	Scilit
Author	Krasutsky, Sergiy G. Zhichkin, Paul E. Beer, Catherine M. Lee, Seung H. Xiong, Jin-Ming
Editor	Rennells, W. Martin
Copyright Year	2011
Description	The aromatic amine in fluoroanilines was protected with 2,2,5,5-tetramethyl-1-aza-2,5-disila-cyclopentane (stabase) in order to direct metalation ortho to the fluorine. A series of novel 2-fluoro-3-aminophenylboronates were prepared after quenching the metalated intermediate with triisopropylborate and deprotection in situ. The presented method is convenient and scalable, because all of the synthetic steps use crude intermediates. Several transformations are carried out in the same pot, and the final boronates are easily purified crystalline materials.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0030-1260019.pdf
Ending Page	1608
Page Count	5
Starting Page	1604
ISSN	00397881
e-ISSN	1437210X
DOI	10.1055/s-0030-1260019
Journal	Synthesis
Issue Number	10
Volume Number	2011
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2011-04-27
Access Restriction	Open
Subject Keyword	Journal: Synthesis Organic Chemistry Protecting Groups
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in