NDLI: Chemopreventive Activity of Isoquinoline Alkaloids from Corydalis Plants

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Chemopreventive Activity of Isoquinoline Alkaloids from Corydalis Plants

Content Provider	Scilit
Author	Ito, Chihiro Itoigawa, Masataka Tokuda, Harukuni Kuchide, Masashi Nishino, Hoyoku Furukawa, Hiroshi
Copyright Year	2001
Description	Eighteen isoquinoline alkaloids including protoberberines (1 - 12), benzophenanthridines (13 - 16) and an aporphine (17) isolated from plants of Corydalis species (Fumariaceae) were tested for inhibitory effects on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol 13-acetate in Raji cells. In a primary screening test, all of the isoquinoline alkaloids showed inhibitory activity with the $IC_{50}$ values being in the range of 140 - 410 mol ratio/32 pmol TPA. The data demonstrate that these isoquinoline alkaloids might be valuable as anti-tumor promoters.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2001-15815.pdf
Ending Page	475
Page Count	3
Starting Page	473
ISSN	00320943
e-ISSN	14390221
DOI	10.1055/s-2001-15815
Journal	Planta Medica
Issue Number	5
Volume Number	67
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2001-12-31
Access Restriction	Open
Subject Keyword	Journal: Planta Medica Medicinal Chemistry Isoquinoline Alkaloids Em Class
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Analytical Chemistry Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science

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