FV HR2 Haplotype as Additional Inherited Risk Factor for Deep Vein Thrombosis in Individuals with a High-Risk Profile

Content Provider	Scilit
Author	D’Andrea, Giovanna Bossone, Anna Coalizzo, Donatella Brancaccio, Vincenzo Ciampa, Antonio Grandone, Elvira Minno, Giovanni Di Margaglione, Maurizio
Copyright Year	2002
Description	A number of strongly linked polymorphisms within the Factor V gene (FV HR2 haplotype) has been identified as a cause of resistance to activated protein C, and has suggested a modest risk factor for vein thrombosis. We investigated the frequency of the HR2 haplotype in 433 consecutive patients with confirmed deep vein thrombosis and 326 controls. The HR2 haplotype was more frequent in patients (15.2%) than in controls (10.1%). The risk of thrombosis among carriers of this haplotype was significantly increased (odds ratio: 1.6 [95% CI: 1.0-2.5]). The estimated risk associated with the HR2 haplotype was 1.8 (95% CI: 1.1-2.9) in subjects with (n = 255), and 1.4 (95% CI: 0.8-2.4) in those without (n = 178) acquired risk factors for vein thrombosis. After adjustment for sex, FV Leiden and FII $A^{20210}$ mutations, the estimated risk of vein thrombosis among carriers of the HR2 haplotype was 1.8 (95% CI: 1.1-2.8). Present data indicate that the HR2 haplotype is independently associated with vein thrombosis among individuals with a highrisk profile.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1612939.pdf
Ending Page	36
Page Count	5
Starting Page	32
ISSN	2567689X
DOI	10.1055/s-0037-1612939
Journal	Thrombosis and Haemostasis
Issue Number	01
Volume Number	87
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2002-01-01
Access Restriction	Open
Subject Keyword	Journal: Thrombosis and Haemostasis Cardiology and Cardiovascular Diseases Hr2 Haplotype Fv Gene Inherited Risk Factors Vein Thrombosis
Content Type	Text
Resource Type	Article
Subject	Hematology