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Antimicrobial activity of fibrinogen and fibrinogen-derived peptides – a novel link between coagulation and innate immunity
| Content Provider | Scilit |
|---|---|
| Author | Mörgelin, Matthias Kasetty, Gopinath Olin, Anders I. Schmidtchen, Artur Herwald, Heiko Påhlman, Lisa I. |
| Copyright Year | 2013 |
| Description | Summary Fibrinogen is a key player in the blood coagulation system, and is upon activation with thrombin converted into fibrin that subsequently forms a fibrin clot. In the present study, we investigated the role of fibrinogen in the early innate immune response. Here we show that the viability of fibrinogen-binding bacteria is affected in human plasma activated with thrombin. Moreover, we found that the peptide fragment GHR28 released from the p-chain of fibrinogen has antimicrobial activity against bacteria that bind fibrinogen to their surface, whereas non-binding strains are unaffected. Notably, bacterial killing was detected in Group A Streptococcus bacteria entrapped in a fibrin clot, suggesting that fibrinogen and coagulation is involved in the early innate immune system to quickly wall off and neutralise invading pathogens. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH12-10-0739.pdf |
| Ending Page | 939 |
| Page Count | 10 |
| Starting Page | 930 |
| ISSN | 2567689X |
| DOI | 10.1160/th12-10-0739 |
| Journal | Thrombosis and Haemostasis |
| Issue Number | 05 |
| Volume Number | 109 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2013-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Thrombosis and Haemostasis Innate Immune Antimicrobial Activity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology |
