Loading...
Please wait, while we are loading the content...
Similar Documents
In vitro Acetylcholinesterase Inhibitory Activity of the Essential Oil from Acorus calamus and its Main Constituents
| Content Provider | Scilit |
|---|---|
| Author | Mukherjee, Pulok Kumar Kumar, Venkatesan Mal, Mainak Houghton, Peter J. |
| Copyright Year | 2007 |
| Description | The in vitro acetylcholinesterase (AChE) inhibitory potential of the hydroalcoholic extract and of the essential oil from Acorus calamus (AC) rhizomes and that of its major constituents were evaluated based on the Ellman’s method. GC/MS analysis of the oil revealed that the major constituents were β-asarone (79.54 %) and α-asarone (8.47 %). The $IC_{50}$ values were obtained for the hydroalcoholic extract, the essential oil, β-asarone and α-asarone and were 182.31 ± 16.78 μg/mL, 10.67 ± 0.81 μg/mL, 3.33 ± 0.02 μM and 46.38 ± 2.69 μM, respectively. Physostigmine was used as standard inhibitor with an $IC_{50}$ value of 0.28 ± 0.015μM. The experimental observations revealed that the AC essential oil and its constituents have significant AChE inhibitory potential. β-Asarone, the major phytoconstituent present in the essential oil, showed the maximum inhibitory potential. |
| Related Links | http://pdfs.semanticscholar.org/861d/77811a35021cc4b5a2d60b0717cef9f7e49d.pdf |
| Ending Page | 285 |
| Page Count | 3 |
| Starting Page | 283 |
| ISSN | 00320943 |
| e-ISSN | 14390221 |
| DOI | 10.1055/s-2007-967114 |
| Journal | Planta Medica |
| Issue Number | 3 |
| Volume Number | 73 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2007-02-07 |
| Access Restriction | Open |
| Subject Keyword | Journal: Planta Medica Integrative and Complementary Medicine Essential Oil Em Class Major Constituents Hydroalcoholic Extract Acorus Calamus |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Analytical Chemistry Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science |
