NDLI: Efficient Alkylation of Nitrogen Heterocycles Using Lithium Salts and Oxygen Leaving Groups

Content Provider	Scilit
Author	Epling, Gary A. Kumar, Anil
Copyright Year	1991
Description	Superior yields of N-alkylated nitrogen heterocycles have been achieved with remarkable regioselectivity. The lithium salt of the heterocycle was prepared by treatment with butyllithium in tetrahydrofuran. Reaction of this salt at room temperature with electrophiles, such as alkyl methanesulfonates and 1,2-epoxypropane, bearing an oxygen leaving group proceeded quantitatively and gave exclusive N-alkylation with no detectable C-alkylation.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-1991-34743.pdf
Ending Page	348
Page Count	2
Starting Page	347
ISSN	09365214
e-ISSN	14372096
DOI	10.1055/s-1991-34743
Journal	Synlett
Issue Number	05
Volume Number	1991
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	1991-01-01
Access Restriction	Open
Subject Keyword	Organic Chemistry Nitrogen Heterocycles
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry

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