NDLI: Facile, Stereocontrolled Synthetic Route towards Bis-functionalised Pyrrolizidines

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Facile, Stereocontrolled Synthetic Route towards Bis-functionalised Pyrrolizidines

Content Provider	Scilit
Author	Jurczak, Janusz Lindner, Marcin Krasiński, Antoni
Copyright Year	2018
Description	A simple and convenient method for the synthesis of bis-functionalised pyrrolizidines starting from readily available N-Cbz-l-prolinal is described. This aldehyde was converted within two concise steps to the corresponding aminoepoxides, which were separately subjected to regioselective cyclisation induced by a reductive cleavage of the Cbz protecting group. The versatile and concise strategy holds great potential for practical application in the straightforward preparation of pyrrolizidine-based drugs and natural products.
Related Links	http://pdfs.semanticscholar.org/d25f/f58d293b0c1aae620ff7e29eb23aa154d544.pdf http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1609582.pdf
Ending Page	4300
Page Count	6
Starting Page	4295
ISSN	00397881
e-ISSN	1437210X
DOI	10.1055/s-0037-1609582
Journal	Synthesis
Issue Number	21
Volume Number	50
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2018-07-23
Access Restriction	Open
Subject Keyword	Journal: Synthesis Organic Chemistry Diastereoselective Synthesis Asymmetric Epoxidation
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

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