NDLI: Cytochrome P450 Substrate Specificities, Substrate Structural Templates and Enzyme Active Site Geometries

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Cytochrome P450 Substrate Specificities, Substrate Structural Templates and Enzyme Active Site Geometries

Content Provider	Scilit
Author	Lewis, D. F. V. Dickins, M. Eddershaw, P. J. Tarbit, M. H. Goldfarb, P. S.
Copyright Year	1999
Description	The structural characteristics of human cytochrome P450 substrates are outlined in the light of extensive studies on P450 substrate specificity. Templates of superimposed substrates for individual P450 isozymes are shown to fit the corresponding enzyme active sites, where contacts with specific amino acid residues appear to be involved in the interaction with each structural template. Procedures leading to the evaluation of likely P450 specificity, binding affinity and rate of metabolism are described in the context of key examples in which molecular modelling appears to rationalize experimentally observed findings.
Related Links	http://www.degruyter.com/downloadpdf/j/dmdi.1999.15.1/dmdi.1999.15.1.1/dmdi.1999.15.1.1.xml
ISSN	07925077
e-ISSN	21910162
DOI	10.1515/dmdi.1999.15.1.1
Journal	Drug metabolism and drug interactions
Issue Number	1
Volume Number	15
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	1999-01-01
Access Restriction	Open
Subject Keyword	Drug Metabolism and Drug Interactions Biochemistry and Molecular Biology Modelling Cytochrome P450 Substrate Specificities Structural Templates P450 Substrate Journal: Drug Metabolism and Drug Interactions, Vol- 15
Content Type	Text
Resource Type	Article
Subject	Pharmacology, Toxicology and Pharmaceutics Pharmacology (medical)

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