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Type 3 renal tubular acidosis associated with growth hormone deficiency
| Content Provider | Scilit |
|---|---|
| Author | Liew, Yin Ping Rogers, Timothy A. Garb, Jane L. Allen, Holley F. Reiter, Edward O. Campfield, Thomas J. Dharnidharka, Vikas R. Braden, Gregory L. |
| Copyright Year | 2017 |
| Abstract | Background:We identified two boys with type 3 renal tubular acidosis (RTA) and growth hormone deficiency and we sought to differentiate them from children with classic type 1 distal RTA.Methods:We reviewed all children Results:All children with type 1 RTA reached the 5th percentile or higher on CDC growth charts within 2 years of alkali therapy. Their mean height standard deviation score (SDS) improved from −1.4 to −0.6 SDS and their mean mid-parental height (MPH) SDS improved from −0.6 to 0 SDS after 2 years. In contrast, the boys with growth hormone deficiency had a height SDS of −1.4 and −2.4 SDS after 2 years of alkali and the MPH SDS were both −2.6 SDS after 2 years of alkali therapy. Growth hormone therapy accelerated their growth to normal levels and led to long-term correction of RTA.Conclusions:A child with type 1 RTA whose height response after 2 years of alkali therapy is inadequate should undergo provocative growth hormone testing. |
| Related Links | http://www.degruyter.com/downloadpdf/j/jpem.2017.30.issue-10/jpem-2016-0460/jpem-2016-0460.xml |
| Ending Page | 1053 |
| Page Count | 7 |
| Starting Page | 1047 |
| ISSN | 21910251 |
| DOI | 10.1515/jpem-2016-0460 |
| Journal | Journal of Pediatric Endocrinology and Metabolism |
| Issue Number | 10 |
| Volume Number | 30 |
| Language | English |
| Publisher | Walter de Gruyter GmbH |
| Publisher Date | 2017-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal of Pediatric Endocrinology and Metabolism Pediatrics and Child Health Growth Hormone Deficiency Renal Tubular Acidosis Journal: Journal of Pediatric Endocrinology and Metabolism, Vol- 30 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Endocrinology Pediatrics, Perinatology and Child Health |
