NDLI: Intrauterine growth restriction and placental gene expression in severe preeclampsia, comparing early-onset and late-onset forms

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Intrauterine growth restriction and placental gene expression in severe preeclampsia, comparing early-onset and late-onset forms

Content Provider	Scilit
Author	Nevalainen, Jaana Skarp, Sini Savolainen, Eeva-Riitta Ryynänen, Markku Järvenpää, Jouko
Copyright Year	2017
Abstract	Objective:To evaluate placental gene expression in severe early- or late-onset preeclampsia with intrauterine growth restriction compared to controls.Study design:Chorionic villus sampling was conducted after cesarean section from the placentas of five women with early- or late-onset severe preeclampsia and five controls for each preeclampsia group. Microarray analysis was performed to identify gene expression differences between the groups.Results:Pathway analysis showed over-representation of gene ontology (GO) biological process terms related to inflammatory and immune response pathways, platelet development, vascular development, female pregnancy and reproduction in early-onset preeclampsia. Pathways related to immunity, complement and coagulation cascade were overrepresented in the hypergeometric test for the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Ten genes (Conclusion:There are significant differences in placental gene expression between severe early- and late-onset preeclampsia when both are associated with intrauterine growth restriction.
Related Links	http://www.degruyter.com/downloadpdf/j/jpme.ahead-of-print/jpm-2016-0406/jpm-2016-0406.xml
Ending Page	877
Page Count	9
Starting Page	869
ISSN	16193997
e-ISSN	03005577
DOI	10.1515/jpm-2016-0406
Journal	Journal of Perinatal Medicine
Issue Number	7
Volume Number	45
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	2017-04-13
Access Restriction	Open
Subject Keyword	Journal of Perinatal Medicine Obstetrics and Gynecology Adverse Pregnancy Outcome Intrauterine Growth Restriction Microarray Severe Early-onset Preeclampsia Severe Late-onset Preeclampsia Journal: Journal of Perinatal Medicine, Vol- 45, Issue- 1
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health Obstetrics and Gynecology

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