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Expression of NF-κB p65 phosphorylated at serine-536 in rectal cancer with or without preoperative radiotherapy
| Content Provider | Scilit |
|---|---|
| Author | Lewander, Andreas Gao, Jinfang Adell, Gunnar Zhang, Hong Sun, Xiao-Feng |
| Copyright Year | 2011 |
| Description | In the present study, we investigated NF-κB p65 phosphorylated at Serine-536 (phosphor-Ser536-p65) in rectal cancer and its relationship to preoperative radiotherapy (RT), clinicopathological variables and biological factors. Expression of phosphor-Ser536-p65 was examined by using immunohistochemistry in 141 primary rectal cancers, 149 normal mucosa specimens and 48 metastases in the lymph nodes, from rectal cancer patients who participated in a Swedish clinical trial of preoperative RT. The expression of phosphor-Ser536-p65 in the cytoplasm increased from normal mucosa to primary tumour (p0.05). Expression of phosphor-Ser536-p65 was positively related to, or tended to be related to, the expression of tumour endothelium marker 1 (TEM1, p=0.02), FXYD-3 (p=0.001), phosphatase of regenerating liver (PRL, p=0.02), p73 (p=0.048) and meningioma associated protein (MAC30, p=0.05) in the group that received RT but there were no such relationships in the group that did not received RT (p>0.05). The expression of phosphor-Ser536-p65 was not related to clinicopathological factors including survival (p>0.05). The increased expression of phosphor-Ser536-p65 may be involved in rectal cancer development. After RT, phosphor-Ser536-p65 seems to be positively related to the biological factors, which associated with more malignant features of tumours. However, phosphor-Ser536-p65 was not directly related to the response of RT based on recurrence and survival. |
| Related Links | http://www.degruyter.com/downloadpdf/j/raon.2011.45.issue-4/v10019-011-0030-7/v10019-011-0030-7.xml https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423756/pdf |
| ISSN | 13182099 |
| e-ISSN | 15813207 |
| DOI | 10.2478/v10019-011-0030-7 |
| Journal | Radiology and oncology |
| Issue Number | 4 |
| Volume Number | 45 |
| Language | English |
| Publisher | Walter de Gruyter GmbH |
| Publisher Date | 2011-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Radiology and oncology Radiology and Oncology Nf-κb, Serine-536 Immunohistochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Oncology |
