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Long-term treatment with GHRH [1-44] amide in prepubertal children with classical growth hormone deficiency.

Content Provider	Scilit
Author	Duck, S. C. Rapaport, R.
Copyright Year	1999
Abstract	A cohort of 20 GH deficient prepubertal patients were treated with GHRH [1-44] 10 micrograms/kg or 20 micrograms/kg twice daily for up to four years (5 patients). GHRH treatment resulted in sustained improvement in height velocity. The mean prepubertal height velocity was 3.57 +/- 1.05 cm/yr pretreatment; 8.49 +/- 1.45 cm/yr at year 1; 6.86 +/- 1.45 cm/yr at year 2; 6.22 +/- 0.74 cm/yr at year 3; and 6.16 +/- 0.97 cm/yr at year 4. IGF-I levels increased and remained within normal range. The difference between the children's and the parents' Ht SD scores significantly diminished from a pretreatment difference of -2.43 to -0.48 after four years of treatment. No adverse effects were noted during treatment. We conclude that twice-daily GHRH [1-44] treatment in a small group of prepubertal GH deficient children resulted in sustained improvement in height and growth velocity, and achieved height SDS approaching closely those of their parents.
Related Links	http://www.degruyter.com/downloadpdf/j/jpem.1999.12.4/jpem.1999.12.4.531/jpem.1999.12.4.531.xml
Ending Page	536
Page Count	6
Starting Page	531
ISSN	21910251
DOI	10.1515/jpem.1999.12.4.531
Journal	Journal of Pediatric Endocrinology and Metabolism
Issue Number	4
Volume Number	12
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	1999-01-01
Access Restriction	Open
Subject Keyword	Journal of Pediatric Endocrinology and Metabolism Endocrinology and Metabolism Children Treatment Ghrh Cm/yr Micrograms/kg Prepubertal Gh Deficient Journal: Journal of Pediatric Endocrinology and Metabolism, Issue- 12
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Endocrinology Pediatrics, Perinatology and Child Health

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