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NGAL and MMP-9/NGAL as biomarkers of plaque vulnerability and targets of statins in patients with carotid atherosclerosis
| Content Provider | Scilit |
|---|---|
| Author | Eilenberg, Wolf Stojkovic, Stefan Kaider, Alexandra Kozakowski, Nicolas Domenig, Christoph M. Burghuber, Christopher Nanobachvili, Josif Huber, Kurt Klinger, Markus Neumayer, Christoph Huk, Ihor Wojta, Johann Demyanets, Svitlana |
| Copyright Year | 2017 |
| Abstract | Background: Neutrophil gelatinase associated lipocalin (NGAL) is expressed in atherosclerotic lesions and was recently implicated in the pathogenesis of cardiovascular pathologies. Statins are known to exert stabilizing effects on atherosclerotic plaque. The aims of our study were (1) to investigate the association of serum NGAL and metalloproteinase (MMP)-9/NGAL complex with the vulnerability of the atherosclerotic plaque, and (2) to reveal the effects of statin treatment on circulating NGAL and MMP-9/NGAL levels in patients with carotid artery stenosis. Methods: We examined the levels of NGAL and MMP-9/NGAL in blood samples from 136 patients with carotid artery stenosis by specific enzyme-linked immunosorbent assays. Results: Patients with vulnerable plaques, as determined by ultrasound (plaques with decreased echogenicity) and histological analysis (type VI according to the classification of American Heart Association [AHA]), displayed the highest levels of NGAL (both p Conclusions: Circulating NGAL and MMP-9/NGAL are associated with plaque vulnerability in patients with carotid artery stenosis. Statin treatment could contribute to plaque stabilization by reducing circulating NGAL and MMP-9/NGAL levels. |
| Related Links | http://www.degruyter.com/downloadpdf/j/cclm.2018.56.issue-1/cclm-2017-0156/cclm-2017-0156.xml |
| Ending Page | 156 |
| Page Count | 10 |
| Starting Page | 147 |
| ISSN | 14346621 |
| e-ISSN | 14374331 |
| DOI | 10.1515/cclm-2017-0156 |
| Journal | Clinical Chemistry and Laboratory Medicine (CCLM) |
| Issue Number | 1 |
| Volume Number | 56 |
| Language | English |
| Publisher | Walter de Gruyter GmbH |
| Publisher Date | 2017-11-27 |
| Access Restriction | Open |
| Subject Keyword | Clinical Chemistry and Laboratory Medicine (cclm) Medical Laboratory Technology Biomarker Carotid Artery Stenosis Neutrophil Gelatinase Associated Lipocalin Plaque Vulnerability Statins Journal: Clinical Chemistry and Laboratory Medicine (CCLM), Vol- 56, Issue- 1 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Clinical Biochemistry |
