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Suppression of inflammatory cytokines expression with bitter melon (Momordica charantia) in TNBS-instigated ulcerative colitis
| Content Provider | Scilit |
|---|---|
| Author | Semiz, Asli Acar, Ozden Ozgun Cetin, Hulya Semiz, Gurkan Sen, Alaattin |
| Copyright Year | 2020 |
| Description | Background and Objective: This study was aimed to elucidate the molecular mechanism of Momordica charantia (MCh), along with a standard drug prednisolone, in a rat model of colitis induced by trinitrobenzene sulfonic acid (TNBS). Methods: After the induction of the experimental colitis, the animals were treated with MCh (4 g/kg/day) for 14 consecutive days by intragastric gavage. The colonic tissue expression levels of C-C motif chemokine ligand 17 (CCL-17), interleukin (IL)-1β, IL-6, IL-23, interferon-γ (IFN-γ), nuclear factor kappa B (NF-kB), and tumor necrosis factor-α (TNF-α), were determined at both mRNA and protein levels to estimate the effect of MCh. Besides, colonic specimens were analyzed histopathologically after staining with hematoxylin and eosin. Results: The body weights from TNBS-instigated colitis rats were found to be significantly lower than untreated animals. Also, the IFN-γ, IL-1β, IL-6, Il-23, TNF-α, CCL-17, and NF-kB mRNA and protein levels were increased significantly from 1.86-4.91-fold and 1.46-5.50-fold, respectively, in the TNBS-instigated colitis group as compared to the control. Both the MCh and prednisolone treatment significantly reduced the bodyweight loss. It also restored the induced colonic tissue levels of IL-1β, IL-6, IFN-γ, and TNF-α to normal levels seen in untreated animals. These results were also supported with the histochemical staining of the colonic tissues from both control and treated animals. Conclusion: The presented data strongly suggests that MCh has the anti-inflammatory effect that might be modulated through vitamin D metabolism. It is the right candidate for the treatment of UC as an alternative and complementary therapeutics. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534491/pdf https://content.sciendo.com/downloadpdf/journals/jtim/8/3/article-p177.pdf |
| ISSN | 2450131X |
| e-ISSN | 22244018 |
| DOI | 10.2478/jtim-2020-0027 |
| Journal | Journal of Translational Internal Medicine |
| Issue Number | 3 |
| Volume Number | 8 |
| Language | English |
| Publisher | Walter de Gruyter GmbH |
| Publisher Date | 2020-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Translational Internal Medicine Journal of Translational Internal Medicine Nutrition and Dietetics Momordica Charantia Ulcerative Colitis Inflammatory Bowel Disease Anti-inflammatory Inflammatory Cytokines Trinitrobenzenesulfonic Acid Immunohistochemistry Alternative and Complementary Therapeutics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Internal Medicine |
