NDLI: Galactosyl Hydroxylysine and Deoxypyridinoline: A Methodological Comparison

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Galactosyl Hydroxylysine and Deoxypyridinoline: A Methodological Comparison

Content Provider	Scilit
Author	Bettica, P. Baylink, D. J. Moro, L.
Copyright Year	1993
Abstract	Galactosyl hydroxylysine and deoxypyridinoline are at present the most promising markers of bone resorption. Various studies have indeed shown that these two markers discriminate with high accuracy subjects with different rates of bone turnover and that their accuracies and discriminate power are very similar. The aim of this paper is to compare the practicality and the reproducibility of the HPLC galactosyl hydroxylysine and deoxypyridinoline assays. In summary, this review shows that the galactosyl hydroxylysine and deoxypyridinoline HPLC assays differ mainly in the need, in using deoxypyridinoline, for an acid hydrolysis and a preextraction of the urine samples. This implies two major problems for deoxypyridinoline: 1) more time is required due to the cumbersome preanalytical procedures; and 2) a lower reproducibility. Our data, in fact, show that both the intra-assay and inter-assay coefficient of variation of the deoxypyridinoline assay are almost 100% higher than those of the galactosyl hydroxylysine assay.
Related Links	https://edoc.hu-berlin.de/bitstream/18452/10482/1/cclm.1993.31.7.459.pdf
ISSN	14346621
e-ISSN	14374331
DOI	10.1515/cclm.1993.31.7.459
Journal	Clinical Chemistry and Laboratory Medicine (CCLM)
Issue Number	7
Volume Number	31
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	1993-01-01
Access Restriction	Open
Subject Keyword	Clinical Chemistry and Laboratory Medicine (cclm) Biochemical Research Analytical Chemistry Methodological Comparison Galactosyl Hydroxylysine and Deoxypyridinoline Journal: Clinical Chemistry and Laboratory Medicine (CCLM), Vol- 31, Issue- 1
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Clinical Biochemistry

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