NDLI: Association study of LIN28B in girls with precocious puberty

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Association study of LIN28B in girls with precocious puberty

Content Provider	Scilit
Author	Chen, Yen-Chun Chen, Li-Min Lin, Hung-Hsun Chen, Bai Hsiun Chao, Mei-Chyn Hsiao, Hui-Pin
Copyright Year	2017
Abstract	Background:Central precocious puberty (CPP), predominant in girls, is defined by early development of secondary sexual characteristics driven by the early secretion of hypothalamic gonadotropin releasing hormone (GnRH) and subsequent gonadotropin. Recent studies have shown variation in theMethods:This study attempted to investigate the relation between single-nucleotide polymorphisms (SNPs) inResults:We found genotype frequencies in rs314276 and rs221634 were significantly correlated with girls with CPP; while the C allele frequency in rs314276 showed the dominant trait. Standard deviation score (SDS) of weight and body mass index (BMI) were higher in CC homozygotes of rs314276 in girls with CPP.Conclusions:Our results demonstrate that the genotype of rs314276 in
Related Links	http://www.degruyter.com/downloadpdf/j/jpem.2017.30.issue-6/jpem-2016-0101/jpem-2016-0101.xml
Ending Page	667
Page Count	5
Starting Page	663
ISSN	21910251
DOI	10.1515/jpem-2016-0101
Journal	Journal of Pediatric Endocrinology and Metabolism
Issue Number	6
Volume Number	30
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	2017-01-01
Access Restriction	Open
Subject Keyword	Journal of Pediatric Endocrinology and Metabolism Medical Laboratory Technology Central Precocious Puberty Lin28b Single-nucleotide Polymorphism Journal: Journal of Pediatric Endocrinology and Metabolism, Vol- 30, Issue- 1
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Endocrinology Pediatrics, Perinatology and Child Health

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