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Decreased Activation of Lecithin: Cholesterol Acyltransferase by Glycated Apolipoprotein A-I

Content Provider	Scilit
Author	Calvo, C. Ulloa, N. Pozo, R. Del Verdugo, C.
Copyright Year	1993
Abstract	Non-enzymatic glycation of plasma proteins may contribute to the excess risk of developing atherosclerosis in patients with diabetes mellitus. Glycated apolipoprotein A-I isolated from diabetic subjects was tested in vitro for its ability to activate lecithin:cholesterol acyltransferase, the principal cholesterol-esterifying enzyme in plasma. Activation by glycated apolipoprotein A-I was significantly lower at all concentrations than the activation by normal apolipoprotein A-I. Linear regression analysis of the kinetic data shows that the ratio app Vmax/app Km was significantly lower (p < 0.01) for glycated apolipoprotein A-I (0.29 nmol.l/h.mumol) than for normal apolipoprotein A-I (0.78 nmol.l/h.mumol). Because lecithin:cholesterol acyltransferase provides a driving force in reverse cholesterol transport by esterifying the cellular cholesterol removed by HDL, it is tempting to postulate that this abnormal activation may be associated with a reduction in reverse cholesterol transport and associated with the accelerated development of atherosclerosis in diabetic patients.
Related Links	https://edoc.hu-berlin.de/bitstream/18452/10287/1/cclm.1993.31.4.217.pdf http://www.degruyter.com/downloadpdf/j/cclm.1993.31.issue-4/cclm.1993.31.4.217/cclm.1993.31.4.217.xml
Ending Page	220
Page Count	4
Starting Page	217
ISSN	14346621
e-ISSN	14374331
DOI	10.1515/cclm.1993.31.4.217
Journal	Clinical Chemistry and Laboratory Medicine (CCLM)
Issue Number	4
Volume Number	31
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	1993-01-01
Access Restriction	Open
Subject Keyword	Clinical Chemistry and Laboratory Medicine (cclm) Endocrinology and Metabolism Diabetic Lecithin Cholesterol Acyltransferase Glycated Apolipoprotein Nmol.l/h.mumol Reverse Proteins Journal: Clinical Chemistry and Laboratory Medicine (CCLM), Vol- 31
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Clinical Biochemistry

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