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Definition of the upper reference limit of glycated albumin in blood donors from Italy

Content Provider	Scilit
Author	Bellia, Chiara Zaninotto, Martina Cosma, Chiara Agnello, Luisa Sasso, Bruna Lo Bivona, Giulia Plebani, Mario Ciaccio, Marcello
Copyright Year	2017
Abstract	Background: Glycated Albumin (GA) has been proposed as a short-term indicator of glycemic homeostasis. The aim of this study is to describe the distribution of GA in a large sample of blood donors from Italy to evaluate whether demographic features, namely age and sex, could influence GA levels and define specific reference limits. Methods: The study included 1334 Italian blood donors. GA was measured using an enzymatic method (quantILab Glycated Albumin, IL Werfen, Germany). The upper reference limit (URL) was calculated using the non-parametric percentile method. Results: A modest, although significant, increase of GA was observed in relation to age (p14.5% presented a mean age of 48.4±12.2 years, 66.7% were males and the mean glucose was 6.88±2.5 mmol/L. Conclusions: GA in Caucasians shows a similar increasing trend at older ages documented in other ethnicities. The definition of the URL in this population could be useful for both clinical studies, which will clarify the role of GA for diagnosing and monitoring diabetes, and will encourage the introduction of GA in clinical practice.
Related Links	http://www.degruyter.com/downloadpdf/j/cclm.2018.56.issue-1/cclm-2017-0179/cclm-2017-0179.xml
Ending Page	125
Page Count	6
Starting Page	120
ISSN	14346621
e-ISSN	14374331
DOI	10.1515/cclm-2017-0179
Journal	Clinical Chemistry and Laboratory Medicine (CCLM)
Issue Number	1
Volume Number	56
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	2017-11-27
Access Restriction	Open
Subject Keyword	Clinical Chemistry and Laboratory Medicine (cclm) Medical Laboratory Technology Blood Donors Diabetes Glycated Albumin Reference Limit Journal: Clinical Chemistry and Laboratory Medicine (CCLM), Issue- 2
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Clinical Biochemistry

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