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Preparation of silk fibroin microspheres by emulsificationdiffusion method for controlled release drug delivery applications
| Content Provider | Scilit |
|---|---|
| Author | Imsombut, Thanonchat Srisa-Ard, Mangkorn Srihanam, Prasong Baimark, Yodthong |
| Copyright Year | 2011 |
| Abstract | Silk fibroin (SF) microspheres containing a model drug were prepared by a simple water-in-oil emulsification-diffusion method. Aqueous SF solution and ethyl acetate were used as water and oil phases, respectively. Methylene Blue was used as a water-soluble model drug. Effect of drug content on microsphere characteristics, drug loading efficiency and drug release behavior was determined. Scanning electron microscopy revealed that drug-loaded SF microspheres were spherical in shape with a smooth surface. The SF microspheres showed predominant random coil SF conformation. All drug loading efficiencies were approximately 50%. An increase in drug/SF ratio could lead to an increase in %drug release and surface erosion after the drug release test. Drug release from SF microspheres is due to SF matrix swelling and surface erosion processes. |
| Related Links | http://www.degruyter.com/dg/viewarticle.fullcontentlink:pdfeventlink/$002fj$002fepoly.2011.11.issue-1$002fepoly.2011.11.1.936$002fepoly.2011.11.1.936.pdf?t:ac=j$002fepoly.2011.11.issue-1$002fepoly.2011.11.1.936$002fepoly.2011.11.1.936.xml |
| Ending Page | 943 |
| Page Count | 8 |
| Starting Page | 936 |
| ISSN | 21974586 |
| e-ISSN | 16187229 |
| DOI | 10.1515/epoly.2011.11.1.936 |
| Journal | e-Polymers |
| Issue Number | 1 |
| Volume Number | 11 |
| Language | English |
| Publisher | Walter de Gruyter GmbH |
| Publisher Date | 2011-12-01 |
| Access Restriction | Open |
| Subject Keyword | E-polymers Biomaterials Pharmacology and Pharmacy Behavior Erosion Model Microspheres Silk Oil Drug Release Fibroin Journal: e-Polymers, Issue- 6 |
| Content Type | Text |
| Resource Type | Article |
