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SARS-CoV-2 serosurvey in health care workers of the Veneto Region
| Content Provider | Scilit |
|---|---|
| Author | Plebani, Mario Padoan, Andrea Fedeli, Ugo Schievano, Elena Vecchiato, Elena Lippi, Giuseppe Cascio, Giuliana Lo Porru, Stefano Palù, Giorgio |
| Copyright Year | 2020 |
| Abstract | Objectives The ongoing outbreak of coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses formidable challenges to all health care systems. Serological assays may be used for improving disease management when appropriately applied, for investigating the antibody responses mounted against SARS-CoV-2 infection and for assessing its real prevalence. Although testing the whole population is impractical, well-designed serosurveys in selected subpopulations in specific risk groups may provide valuable information. We evaluated the prevalence of SARS-CoV-2 infection in health care workers (HCW) who underwent molecular testing with reverse transcription real-time polymerase chain reaction (rRT-PCR) in the main hospitals of the Veneto Region of Italy by measuring specific antibodies (Abs). Methods Both immunoglobulin (Ig)M and IgG antibodies against SARS-Cov-2 S-antigen and N-protein were measured using a validated chemiluminescent analytical system (CLIA) called Maglumi™ 2000 Plus (New Industries Biomedical Engineering Co., Ltd [Snibe], Shenzhen, China). Results A total of 8,285 HCW were tested. SARS-CoV-2 specific antibodies (IgM, IgG or both) were detectable in 378 cases (4.6%, 95% CI 4.1–5.0%). Seroconversion was observed in 4.4% of women vs. 5.0% of men, but this difference was not significant. Although detectable antibodies were found in all HCW who developed severe COVID-19 infection (100%), lower seropositivity was found in mild disease (83%) and the lowest prevalence (58%) was observed in asymptomatic subjects. Conclusions Seroprevalence surveys are of utmost importance for understanding the rate of population that has already developed antibodies against SARS-CoV-2. The present study defined precisely the circulation of SARS-CoV-2 in a cohort of HCW in the Veneto Region, with its prevalence (4.6%) reflecting a relatively low circulation. Symptomatic individuals or those hospitalized for medical care were 100% antibody positive, whilst Abs were only detectable in 58% of asymptomatic carriers. |
| Related Links | https://www.degruyter.com/downloadpdf/journals/cclm/ahead-of-print/article-10.1515-cclm-2020-1236/article-10.1515-cclm-2020-1236.pdf |
| Ending Page | 2111 |
| Page Count | 5 |
| Starting Page | 2107 |
| ISSN | 14346621 |
| e-ISSN | 14374331 |
| DOI | 10.1515/cclm-2020-1236 |
| Journal | Clinical Chemistry and Laboratory Medicine (CCLM) |
| Issue Number | 12 |
| Volume Number | 58 |
| Language | English |
| Publisher | Walter de Gruyter GmbH |
| Publisher Date | 2020-11-26 |
| Access Restriction | Open |
| Subject Keyword | Clinical Chemistry and Laboratory Medicine (cclm) Nutrition and Dietetics Covid-19 Health Care Workers Sars-cov-2 Antibody Seroprevalence Journal: Clinical Chemistry and Laboratory Medicine (CCLM), Vol- 58 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Clinical Biochemistry |
