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Electrospun coaxial hyaluronan-based fiber networks for ophthalmic drug release
| Content Provider | Scilit |
|---|---|
| Author | Walter, Torsten Wyrwa, Ralf Altmann, Cindy Schnabelrauch, Matthias |
| Copyright Year | 2021 |
| Abstract | A micro-sized core-shell drug release device has been prepared by coaxial electrospinning based on a polylactide shell and the inner core phase made of high molecular weight hyaluronan or a cross-linked hyaluronan network. Timolol, which was inserted into the core phase, is widely used as drug for glaucoma treatment to depress the intraocular eye pressure and should be released over a longer time period from this fiber networks. Release studies of drug loaded fiber devices showed an only moderate burst release of timolol in the first days followed by a continuous longlasting drug release period over several weeks. With these findings, coaxial electrospinning represents a promising approach for the development of drug release systems with long-lasting, relatively constant drug delivery. |
| Related Links | https://www.degruyter.com/document/doi/10.1515/cdbme-2021-2175/pdf |
| Ending Page | 691 |
| Page Count | 4 |
| Starting Page | 688 |
| e-ISSN | 23645504 |
| DOI | 10.1515/cdbme-2021-2175 |
| Journal | Current Directions in Biomedical Engineering |
| Issue Number | 2 |
| Volume Number | 7 |
| Language | English |
| Publisher | Walter de Gruyter GmbH |
| Publisher Date | 2021-10-01 |
| Access Restriction | Open |
| Subject Keyword | Current Directions in Biomedical Engineering Anesthesiology Coaxial Electrospinning Long-term Drug Release Polylactide Hyaluronan Ophthalmology Journal: Current Directions in Biomedical Engineering, Vol- 7, Issue- 1 |
| Content Type | Text |
| Resource Type | Article |
