NDLI: Antithrombin improves the maternal and neonatal outcomes but not the angiogenic factors in extremely growth-restricted fetuses at <28 weeks of gestation

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Antithrombin improves the maternal and neonatal outcomes but not the angiogenic factors in extremely growth-restricted fetuses at <28 weeks of gestation

Content Provider	Scilit
Author	Fujisaki, Midori Furuta, Ken Ohhashi, Masanao Furukawa, Seishi Kodama, Yuki Kawagoe, Yasuyuki Sameshima, Hiroshi Ikenoue, Tsuyomu
Copyright Year	2016
Abstract	Aims:Severe preterm fetal growth restriction (FGR) remote from term is problematic. We aimed to investigate the effect of maternally-administered antithrombin on maternal and neonatal outcomes. A prospective, one-arm, pilot study was performed in 14 women with severe FGR (≤5Results:In group 1 (n=4), their pregnancies were extended for longer periods and the maternal and infant outcomes were good. The prolongation periods were shorter in groups 2 (n=3) and 3 (n=7), which resulted in poor maternal [severe preeclampsia or hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome] and infant outcomes.Conclusions:The evaluation of the maternal sFlt-1 and PlGF at 21–27 weeks of gestation is useful in the managements of severe FGR. Antithrombin treatment could prolong the pregnancies with low sFlt-1 and high PlGF without negatively affecting maternal or fetal health.
Related Links	http://www.degruyter.com/downloadpdf/j/jpme.2017.45.issue-7/jpm-2016-0190/jpm-2016-0190.xml
Ending Page	842
Page Count	6
Starting Page	837
ISSN	16193997
e-ISSN	03005577
DOI	10.1515/jpm-2016-0190
Journal	Journal of Perinatal Medicine
Issue Number	7
Volume Number	45
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	2016-12-03
Access Restriction	Open
Subject Keyword	Journal of Perinatal Medicine Pediatrics and Child Health Antithrombin Fetal Growth Restriction Perinatal Mortality Placenta Journal: Journal of Perinatal Medicine, Issue- 2
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health Obstetrics and Gynecology

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