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Perioperative radiotherapy versus surgery alone for retroperitoneal sarcomas: a systematic review and meta-analysis
| Content Provider | Scilit |
|---|---|
| Author | Diamantis, Alexandros Baloyiannis, Ioannis Magouliotis, Dimitrios Tolia, Maria Symeonidis, Dimitrios Bompou, Effrosyni Polymeneas, Georgios Tepetes, Konstantinos |
| Copyright Year | 2020 |
| Abstract | Background: There is no clear evidence on whether radiotherapy (RT) improves treatment result in patients with retroperitoneal sarcomas (RPS). Methods: A systematic literature search was performed using PubMed, Scopus and CENTRAL databases. Data were retrieved from published comparatives studies in patients with RPS undergoing surgery alone or RT plus surgery. The primary endpoints were the 5-year OS and the median OS. The secondary endpoints were the recurrence-free survival (RFS) and the R0-resection rate. Continuous outcomes were calculated by means of weighted mean difference (WMD). Results: Ten out of 374 articles were analyzed. The median OS and the 5-year survival were significantly increased in patients treated with RT and surgery, compared to patients treated with surgery alone (p < 0.00001, p < 0.001). Median RFS was significantly increased in patients treated with either preoperative (p < 0.001) or postoperative (p = 0.001) RT compared to patients that underwent surgery alone. Finally, median R0-resection rate was similar between the two groups (p = 0.56). Conclusion: RT along with radical surgery could be the standard of care in at least a subgroup of patients with RPS. |
| Related Links | https://content.sciendo.com/downloadpdf/journals/raon/54/1/article-p14.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087419/pdf https://content.sciendo.com/downloadpdf/journals/raon/ahead-of-print/article-10.2478-raon-2020-0012.pdf |
| Ending Page | 21 |
| Page Count | 8 |
| Starting Page | 14 |
| ISSN | 13182099 |
| e-ISSN | 15813207 |
| DOI | 10.2478/raon-2020-0012 |
| Journal | Radiology and oncology |
| Issue Number | 1 |
| Volume Number | 54 |
| Language | English |
| Publisher | Walter de Gruyter GmbH |
| Publisher Date | 2020-02-29 |
| Access Restriction | Open |
| Subject Keyword | Radiology and Oncology Pediatrics and Child Health Adjuvant Radiotherapy Neoadjuvant Radiotherapy Soft Tissue Sarcoma Journal: Radiology and oncology, Issue- 3-4 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Oncology |
