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Neuroprotective mechanisms of erythropoietin in a rat stroke model
| Content Provider | Scilit |
|---|---|
| Author | Juenemann, Martin Braun, Tobias Schleicher, Nadine Yeniguen, Mesut Schramm, Patrick Gerriets, Tibo Ritschel, Nouha Bachmann, Georg Obert, Martin Schoenburg, Markus Kaps, Manfred Tschernatsch, Marlene |
| Copyright Year | 2020 |
| Abstract | Objective: This study was designed to investigate the indirect neuroprotective properties of recombinant human erythropoietin (rhEPO) pretreatment in a rat model of transient middle cerebral artery occlusion (MCAO).Methods: One hundred and ten male Wistar rats were randomly assigned to four groups receiving either 5,000 IU/kg rhEPO intravenously or saline 15 minutes prior to MCAO and bilateral craniectomy or sham craniectomy. Bilateral craniectomy aimed at elimination of the space-consuming effect of postischemic edema. Diagnostic workup included neurological examination, assessment of infarct size and cerebral edema by magnetic resonance imaging, wet–dry technique, and quantification of hemispheric and local cerebral blood flow (CBF) by flat-panel volumetric computed tomography.Results: In the absence of craniectomy, EPO pretreatment led to a significant reduction in infarct volume (34.83 ± 9.84% vs. 25.28 ± 7.03%; p = 0.022) and midline shift (0.114 ± 0.023 cm vs. 0.083 ± 0.027 cm; p = 0.013). We observed a significant increase in regional CBF in cortical areas of the ischemic infarct (72.29 ± 24.00% vs. 105.53 ± 33.10%; p = 0.043) but not the whole hemispheres. Infarct size-independent parameters could not demonstrate a statistically significant reduction in cerebral edema with EPO treatment.Conclusions: Single-dose pretreatment with rhEPO 5,000 IU/kg significantly reduces ischemic lesion volume and increases local CBF in penumbral areas of ischemia 24 h after transient MCAO in rats. Data suggest indirect neuroprotection from edema and the resultant pressure-reducing and blood flow-increasing effects mediated by EPO. |
| Related Links | https://www.degruyter.com/downloadpdf/journals/tnsci/11/1/article-p48.pdf |
| Ending Page | 59 |
| Page Count | 12 |
| Starting Page | 48 |
| ISSN | 20813856 |
| e-ISSN | 20816936 |
| DOI | 10.1515/tnsci-2020-0008 |
| Journal | Translational Neuroscience |
| Issue Number | 1 |
| Volume Number | 11 |
| Language | English |
| Publisher | Walter de Gruyter GmbH |
| Publisher Date | 2020-05-18 |
| Access Restriction | Open |
| Subject Keyword | Translational Neuroscience Emergency Medicine Neuroprotection Rat Recombinant Human Erythropoietin Transient Focal Cerebral Ischemia Vascular Disorders Craniectomy Journal: Translational Neuroscience, Vol- 11, Issue- 1 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
