NDLI: Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever

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Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever

Content Provider	Scilit
Author	Kurt, Yasemin Gulcan Cayci, Tuncer Öngürü, Pinar Akgul, E. Ozgur Yaman, Halil Aydin, Ibrahim Bodur, Hurrem Türker, Türker Kurt, Ismail Cevik, M. Aydin Erbil, M. Kemal
Copyright Year	2009
Abstract	Crimean-Congo hemorrhagic fever (CCHF) is a public health problem in many countries. Chitotriosidase (ChT) is an enzyme secreted by activated macrophages that catalyzes the hydrolysis of chitin and chitin-like substrates. The goal of this study was to assess the relationship between serum ChT activity and mortality. ChT activities on the first day of hospitalization were analyzed in serum from 46 patients with CCHF and 36 healthy controls. Serum ChT activities and other clinical and laboratory parameters for patients with non-fatal and fatal CCHF were compared. The median ChT activity was increased in all patients with CCHF [189.9 (134.8-246.6) nmol/mL/h]. The median ChT activity in the non-fatal CCHF group [220.2 (180.6-290.1) nmol/mL/h] was higher compared with the fatal CCHF group [29.2 (16.5-45.7) nmol/mL/h] (p<0.001). In univariate analysis, platelet count, lactate dehydrogenase (LDH), and activated partial thromboplastin time were associated with mortality. This is the first study investigating the association of serum ChT enzyme activity with mortality from CCHF. This study suggested that relatively low ChT enzyme activities may be a prognostic marker in patients with CCHF.
Related Links	https://edoc.hu-berlin.de/bitstream/18452/13743/1/cclm.2009.347.pdf
ISSN	14346621
e-ISSN	14374331
DOI	10.1515/cclm.2009.347
Journal	Clinical Chemistry and Laboratory Medicine (CCLM)
Issue Number	12
Volume Number	47
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	2009-01-01
Access Restriction	Open
Subject Keyword	Clinical Chemistry and Laboratory Medicine (cclm) Medical Laboratory Technology Chitotriosidase Enzyme Activity Crimean-congo Hemorrhagic Fever Mortality Journal: Clinical Chemistry and Laboratory Medicine (CCLM), Vol- 47
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Clinical Biochemistry

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