Loading...
Please wait, while we are loading the content...
Similar Documents
Degradation to sulphate of S-methyl-L-cysteine sulphoxide and S-carboxymethyl-L-cysteine sulphoxide in man.
| Content Provider | Scilit |
|---|---|
| Author | Waring, R. H. Harris, R. M. Steventon, G. B. Mitchell, S. C. |
| Copyright Year | 2003 |
| Abstract | A nearly complete recovery of radioactivity was achieved over 14 days following the oral administration of [35S]-S-methyl-L-cysteine sulphoxide and [35S]-S-carboxymethyl-L-cysteine sulphoxide to four healthy male volunteers. The urine was the major pathway of excretion of radioactivity (c. 96% in 0-14 days; c. 59% in 0-24 hours), with the faecal route being relatively unimportant (c. 1.7% in 0-3 days). Inorganic sulphate was an important degradation product, incorporating a substantial proportion of radioactive sulphur derived from these molecules (c. 40% in 0-14 days; c. 20% in 0-24 hours). Subtle differences were noted in the pattern of radioactive sulphate excretion following administration of the two cysteine-sulphoxide compounds, suggesting that their sulphur-containing moieties may enter different catabolic routes. |
| Related Links | http://www.degruyter.com/downloadpdf/j/dmdi.2003.19.4/dmdi.2003.19.4.241/dmdi.2003.19.4.241.xml |
| Ending Page | 256 |
| Page Count | 16 |
| Starting Page | 241 |
| ISSN | 07925077 |
| e-ISSN | 21910162 |
| DOI | 10.1515/dmdi.2003.19.4.241 |
| Journal | Drug metabolism and drug interactions |
| Issue Number | 4 |
| Volume Number | 19 |
| Language | English |
| Publisher | Walter de Gruyter GmbH |
| Publisher Date | 2003-01-01 |
| Access Restriction | Open |
| Subject Keyword | Drug Metabolism and Drug Interactions Anesthesiology Degradation Sulphate Administration Radioactive Faecal 35s Cysteine Sulphoxide Substantial Journal: Drug metabolism and drug interactions, Vol- 19 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology, Toxicology and Pharmaceutics Pharmacology (medical) |
